Author: Babak J. Orandi, MD, PhD, MSc, FACS

Learning Objectives:

1. Define and diagnose MASH using current nomenclature 
2. Describe the epidemiologic burden and natural history of MASH
3. Select an evidence-based management strategy for MASH 

Author: James Shapiro, MD, PhD, FRSC

Learning Objectives:

1. Understand the relative potential benefits of pancreas vs islet transplant
2. Appropriately assign patients for consideration of pancreas vs islet transplant 
3. Understand that both treatments currently require full dose immune suppression to prevent allograft rejection (or recurrence of T1D autoimmunity)
4. Describe short and long term outcomes with patient and graft survival in whole pancreas transplantation, and that metabolically endocrine function currently remains superior with a whole graft
5. Describe the technical implantation technique for pancreas (Y-graft, systemic venous drainage, enteric exocrine drainage), vs intraportal non-surgical percutaneous transhepatic access for islet transplantation
6. Describe recent research progress with stem cell derived islets could one day provide successful transplants with less (or no) immune suppression

Title: From the Author’s Desk: Innovations in Organ Recovery to Expand the Donor Pool: U.S. and Spanish Approaches to DCD and NRP

Speakers: Drs. Ángel Ruiz, MD of the Hospital Clinic Barcelona, and Jeffrey Stern, MD of NYU Langone

Moderators: Drs. Aleah Brubaker, MD, PhD of UCSD and Chloë Ballesté, MD, PhD of the DTI Foundation, Barcelona

Author: Nitin Katariya, MD, FACS

Learning Objectives:

1. Discuss how to get to a successful pancreas transplant based on donor and recipient matching
2. Emphasize why selection matters
3. Understand the donor data and risk
4. Review imaging and pancreas qualities
5. Assess anatomy, logistics, and decisions

Author: Nitin Katariya, MD, FACS

Learning Objectives:

1. Recognize, diagnose, and manage early surgical complications:
   1. Bleeding, wound infection, graft thrombosis, parenchymal leak, enteric leak, graft pancreatitis, AVF, abscess, bowel obstruction
2. Recognize, diagnose, and manage late surgical complications:
   1. Hernia, bowel obstruction, arterial pseudoaneurysm, vascular stenosis

Pancreas Transplantation

Ryan A. Helmick, MD

Learning Objectives

1. Review the history and formation of the Organ Procurement & Transplant Network (OPTN), as well as its relationship with HRSA and UNOS
2. Identify the functions of the OPTN
3. Discuss how transplant centers relate to the OPTN

A recorded webinar on the topic of simultaneous liver-kidney (SLK) vs. the safety-net approach. Hear from the opposing perspectives from presenting fellows, followed by a Q&A and discussion.

Northwestern University: Pro-SLK

• Fellow presenter: Valeria Valbuena, MD
• Faculty advisor: Vinayak Rohan, MD

University of California, San Francisco: Pro-Safety Net

• Mignote Yilma, MD
• Hillary Braun, MD

Author: Colleen Jay, MD, MSCI, FACS

Learning Objectives:

1. Review the pathophysiology and consequences of brain death.
2. Provide updated evidence-based guidelines for medical management of potential donors.
3. Touch on organ donor evaluation and allocation considerations.
4. Understand the pathophysiology of ischemia reperfusion injury and review the basics of common preservation fluids.

Unit Objectives

I. Understand the moral, ethical and legal issues and steps involved in determining brain death.
II. Understand the moral, ethical and legal issues and steps involved in live organ donation.
III. Describe the basic assessment of the medical, laboratory, and anatomic characteristics of a potential organ donor (live or deceased), the quality of a donor organ, and its suitability for a given recipient.
IV. Outline in detail the procedure to safely recover abdominal organs from deceased donors, including those for donation after cardiac death (DCD).
V. Understand the recovery processes for living donor organs and describe the steps necessary to perform relevant organ specific recovery (liver, kidney, or pancreas).
VI. Outline the basic principles and limits of organ preservation and be familiar with organ preservation techniques, including pulsatile perfusion.