Resident Curriculum Unit 1: Pharmacology & Immunosuppression

Unit Objectives

I. Explain the basic pharmacology (mechanisms of action, metabolism, adverse effects, potential interactions, dosing strategies, and target levels) for all immunosuppressive agents in current clinical use.
II. Outline potential complications and clinical and laboratory markers of over- and under-immunosuppression.
III. Define the donor and recipient factors which impact the use of immunosuppressive agents including the risk of rejection, infection, and malignancy.
IV. Identify the clinical and pathologic features of acute and chronic cellular and humoral rejection and implement appropriate pharmacologic therapy; identify short and long term ramifications of rejection episodes.