Resident Curriculum Unit 1: Pharmacology & Immunosuppression
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Unit Objectives
I. Explain the basic pharmacology (mechanisms of action, metabolism, adverse effects, potential interactions, dosing strategies, and target levels) for all immunosuppressive agents in current clinical use.
II. Outline potential complications and clinical and laboratory markers of over- and under-immunosuppression.
III. Define the donor and recipient factors which impact the use of immunosuppressive agents including the risk of rejection, infection, and malignancy.
IV. Identify the clinical and pathologic features of acute and chronic cellular and humoral rejection and implement appropriate pharmacologic therapy; identify short and long term ramifications of rejection episodes.
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Contains 5 Component(s), Includes Credits
Oya M. Andacoglu, MD
1. Understand the general classes/groups of agents and mechanism of action
2. Appreciate the concern, possible mechanism and unintended side effects
3. Identify CNI minimization and CNI free protocols as viable alternatives with focus updated data on benefits and risk compared to CNI based immunosuppression
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Contains 5 Component(s), Includes Credits
Michael Mengel, MD
Author: Michael Mengel, MD
Learning Objectives
1. To review the pathomechanisms of acute and chronic kidney allograft injury
2. To understand the Banff classification system for diagnosing acute and chronic kidney allograft injury
3. To highlight the limitations of the current Banff classification system
4. To discuss future developments to increase diagnostics precision in acute and chronic kidney allograft injury
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Contains 6 Component(s), Includes Credits
Allan Kirk, MD
Author: Allan Kirk, MD
Learning Objectives
1. Definition of acute and chronic allograft rejection
2. Cellular effector mechanisms of rejection
3. Variables influencing alloreactivity
4. Acellular effector mechanisms of rejection
5. Variables influencing alloantibody reactivity
6. Overview of complement activation
7. Mediators of intracellular communication
8. Co-stimulator molecules
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Contains 6 Component(s), Includes Credits
Allan Kirk, MD
Author: Allan Kirk, MD
Learning Objectives
1. Describe Basic Immunology – adaptive or specific immunity
2. Describe the relationship between antigen presenting cells and cytokines released by cells of the innate immune response
3. Describe the types of antigen presenting cells and the changes that occur following exposure to antigen
4. List the subsets of T cells and describe their function
5. Describe the distribution of MHC Class I and Class I molecules on immune cells and commonly transplanted organs
6. Describe the function of MHC Class I and Class II antigens
7. Define the first, second, and third signals involved in the initiation of an effective antigen specific response
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Contains 5 Component(s), Includes Credits
Oya M. Andacoglu, MD
1. Understand the general classes/groups of agents and mechanism of action
2. Appreciate the concern, possible mechanism and unintended side effects
3. Identify CNI minimization and CNI free protocols as viable alternatives with focus updated data on benefits and risk compared to CNI based immunosuppression -
Contains 5 Component(s), Includes Credits
Michael Mengel, MD
Author: Michael Mengel, MD
Learning Objectives
1. To review the pathomechanisms of acute and chronic kidney allograft injury
2. To understand the Banff classification system for diagnosing acute and chronic kidney allograft injury
3. To highlight the limitations of the current Banff classification system
4. To discuss future developments to increase diagnostics precision in acute and chronic kidney allograft injury
-
Contains 6 Component(s), Includes Credits
Allan Kirk, MD
Author: Allan Kirk, MD
Learning Objectives
1. Definition of acute and chronic allograft rejection
2. Cellular effector mechanisms of rejection
3. Variables influencing alloreactivity
4. Acellular effector mechanisms of rejection
5. Variables influencing alloantibody reactivity
6. Overview of complement activation
7. Mediators of intracellular communication
8. Co-stimulator molecules -
Contains 6 Component(s), Includes Credits
Allan Kirk, MD
Author: Allan Kirk, MD
Learning Objectives
1. Describe Basic Immunology – adaptive or specific immunity
2. Describe the relationship between antigen presenting cells and cytokines released by cells of the innate immune response
3. Describe the types of antigen presenting cells and the changes that occur following exposure to antigen
4. List the subsets of T cells and describe their function
5. Describe the distribution of MHC Class I and Class I molecules on immune cells and commonly transplanted organs
6. Describe the function of MHC Class I and Class II antigens
7. Define the first, second, and third signals involved in the initiation of an effective antigen specific response