Minimization of Calcineurin Inhibitors (CNIs) in Kidney Transplantation: Part I


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Author: Belinda T. Lee, MD

1. Understand the general classes/groups of agents and mechanism of action (ie CNI, mTOR, antimetabolites, corticosteroids, co-stimulation blockage) 
2. Appreciate the concern, possible mechanism and unintended side effects of CNI nephrotoxicity
3. Identify CNI minimization and CNI free protocols as viable alternatives with focus updated data on on benefits and risk compared to CNI based immunosuppression

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