Author: Lisa A. Coscia, RN, BSN, CCTC

1. What is the TPRI
2. Describe maternal conditions that can complicate pregnancies and their incidence in various organ transplant recipients.
3. Describe newborn potential outcomes/complications and their incidence in various organ transplant recipients.
4. Know the risks of immunosuppressive medications to the fetus.
5. What are the AST consensus guidelines on the timing of planned pregnancies

Learning Objectives:

•To understand the basic immunologic principles that place transplant recipients at greater risk of cancer after transplant
•To review the increased risks of specific cancers and cancer rates within specific transplant populations
•To outline principles of post-transplant cancer surveillance and recommendations for surveillance
•To discuss the etiology and management of Post-Transplant Lymphoproliferative Disorder

Author: Ryan A. Helmick, MD

1. Recognize the appearance of the three most common types of skin cancer
2. Understand the epidemiology and impact of immunosuppression on skin cancer incidence
3. Be able to educate patients on risk factors, prevention, and treatments for skin cancers
4. Understand the role of immunosuppression in the development of skin cancer (the section on the amount and varieties)
5. Recognize the incidence of skin cancer is affected by the type of transplanted organ
6. Understand the significance of actinic keratosis - that it requires aggressive treatment

Author: Clark C. Otley, MD

Author: Valentina Stosor, MD

Learning Objectives: 

1. Review the common infectious CNS syndromes in transplant recipients
2. Outline the diagnostic approach when CNS infection is suspected
3.  Understand the differential diagnosis for infectious and non-infectious CNS disorders following transplantation

Author: Valentina Stosor, MD

Learning Objectives:

1.  Review common pathogens encountered in posttransplant CNS infections
2.  Define the clinical presentation, diagnostic features, therapies, and prognosis of the common CNS infections

Author: Michael G. Ison, MD, MS

Learning Objectives: 

1) Identify the behavioral and medical risk factors that qualify a donor as “increased-risk of disease transmission.”

2) Describe the sensitivity of NAT testing for HIV, HBV, HCV and quantitate the risk of transmission of new infection in the setting “window-period” negative test results.

Author: Jason Vanatta, MD

University of Louisville

1.  Understand the risk for donor-transmitted malignancies to potential recipients.
2.  Develop an approach to guide decisions regarding a particular donor and to frame the discussion with potential recipients
3.  Recognize the options for treatment in the event that a transmission event is encountered
4.  Understand the regulatory requirements for an identified event

1. Identify typical opportunistic infections associated with transplantation
2. Explain the time points post-transplantation certain types of opportunistic infections are usually observed
3. State the management of immunosuppression for a transplant patient with an opportunistic infections
4. Define the association between CMV infection, acute rejection, and long-term graft outcomes

Author: Jeffrey Tessier, MD, FACP, FIDSA

Author: Michael G. Ison, MD, MS

Learning Objectives:

1. Background: understand what is BK virus, prevalence, viral reactivation
2. Appreciate the clinical significance of BK after kidney transplantation (prevalence, course, manifestations and effect on graft survival)
3. Algorithm for surveillance, diagnosis and stages of BK infection and BK nephritis
4. Treatment options
5. Retransplantation in patients with graft loss due to BK nephropathy

Author: Eva A. Piessens, MD, MPH

1. Understand the risk factors, prophylactic and treatment strategies, and post transplant manifestations of CMV reactivation and disease.  
2. Understand the risk factors, prophylactic and treatment strategies, and post transplant manifestations of EBV as it is associated with PTLD.
3. Understand the impact of the other Herpes viruses including HSV1 and 2, Varicella zoster virus, HHV-6, HHV-7, and HHV-9.