Major Histocompatibility Complex Part II: Clinical significance of anti-HLA antibodies in transplantation
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Author: Kelley M.K. Hitchman, MS, PhD, F(ACHI)
Learning Objectives:
- Review the history and evolution of diagnostic criteria for antibody mediated rejection (AMR).
- Describe mechanisms in which mismatched donor HLA antigens can cause and contribute to AMR.
- Explain the components and process of performing a virtual crossmatch, as well as how it is applied as a specialized immunologic risk assessment for transplant pairs.
- Summarize different timings and manifestations of AMR.
- Understand how HLA-DSA detection can correlate with rejection and how anti-HLA antibody testing can help inform desensitization.
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Video
Open to view video. | Closed captions available | 24 minutes
Open to view video. | Closed captions available | 24 minutes
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Quiz
3 Questions | Unlimited attempts | 0/3 points to pass
3 Questions | Unlimited attempts | 0/3 points to pass
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1.00 Completion credit | No certificate available
1.00 Completion credit | No certificate available