Major Histocompatibility Complex Part I: Structure and Function of HLA

Author: Kelley M.K. Hitchman, MS, PhD, F(ACHI)

Learning Objectives:

  1. List key genes of the Major Histocompatibility Complex (MHC) encoding for HLA molecules and describe MHC inheritance.
  2. Summarize MHC and HLA polymorphism, HLA molecule expression and HLA molecule functions.
  3. Appraise the role of HLA molecules and peptides in transplantation.
  4. Describe test methods utilized by clinical histocompatibility & immunogenetics laboratories for the purposes of HLA typing and anti-HLA antibody detection/identification, as well as the clinical applications of such HLA data.

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