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Acute Liver Failure

1. Define acute on top of chronic liver failure (ACLF)

2. Impact of ACLF/scoring systems (CLIF-SOFA scoring)
      Survival / mortality risk in ACLF
      Prevalence of ACLF among inhouse liver patients with cirrhosis
      Financial burden of ACLF
3. Pathophysiology and clinical presentation of ACLF
      Predisposing factors: (acute liver injury on top of chronic, extrahepatic process “bleed – infection”, un identified)
      Predisposition: (Genetic, Gut/ microbiotia, infection)
      Pathophysiology (SIRS, infection, MOF) 
4. Management?
      Medial management – role of liver support systems
      Prognostic criteria for survival
      To transplant or not ---Futile Transplant
      Role of LDLT

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Author: Sameh Adel Fayek, MD, PhD

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